SIMULATION OF AGING IN SILICO

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The model with 2 glands and 3 glands

Download the model, run it (for example, in Windows it can be a double-click) V. A. Chistyakov, Y. V. Denisenko (2012) «Cellularity loss and the Dilman’s problem: in silico research», Biochemistry 77, 936 - 951.

JRE 7 or later is required to run model.

Terminology

Average	The average level of motoneurons programmed cellular death (PCD) inductors
Deviation	The standard deviation of PCD inductors level sample
Threshold	The threshold magnitude of PCD inductors level, starting PCD of motoneurons
Number of days	Period of the modelled populations observation
Death threshold of an individual	Cellularity loss level, threshold for a death of an individual
Number of individuals (0-5000)	Number of individuals in a population
Number of motoneurons	Number of motoneurons in one individual
Shift	The magnitude by which decreases the level of PCD inductors in individuals, exposed to the experimental geroprotector influence
The start of processing	The first day of geroprotector introduction
The end of processing	The last day of geroprotector introductionch
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